Monday, May 3, 2010

Some nerdy RNA structure stuff

Just thought I should let you know there is a recent decimal release of RFAM (10.0), most novelties are a consequence of the Infernal 1.0 release although there are also nomenclature changes that are quite convenient. It now contains 1446 ncRNA families, including the self-proclaimed "deepest alignment of all time" containing over 1 million tRNA sequences. Read more here.

Also, I know that some of you are interested in generating secondary structures for your favorite RNAs. I just discovered this amazing website that allows users to display 2D RNA structures comprehensively. There was a recurring problem with most 2D RNA display programs as they weren't flexible with the representation, e.g. overlapping stems would mess up your nature paper figure. This program, VARNA, even accommodates pseudo-knots and uses animations to switch between sub-optimal structures :) Check it out here.

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